Metabolism Ketamine is metabolized via N-dealkylation into the Energetic metabolite norketamine largely by CYP2B6 and CYP3A4 also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation on the cyclohexone ring to variety hydroxynorketamine compounds by using CYP-dependent pathways, which are conjugated with glucuronic acid and